MOTS-C 10 mg

MOTS-c Research Peptide – 10mg Vial

MOTS-c is a mitochondrial-derived peptide composed of 16 amino acids, encoded within the 12S rRNA gene of the mitochondrial genome. It comes as a freeze-dried powder in a 10 mg glass vial, supplied for laboratory research into mitochondrial signaling and metabolic regulation.

Why Researchers Are Interested In It:

Because it functions as a retrograde signaling molecule from the mitochondria to the nucleus, MOTS-c is a popular subject in lab research. Most of this work is done in cell cultures and animal models, where scientists look at:

• Mitochondrial signaling: How signals originate in the mitochondria and travel to the nucleus to regulate gene expression.
• AMPK activation: How the peptide interacts with AMP-activated protein kinase pathways to influence cellular energy homeostasis.
• Metabolic flexibility: How cells adapt glucose and fatty acid metabolism under stress or exercise-mimicking conditions.

FOR LABORATORY RESEARCH USE ONLY: This product is a research chemical. It is not a drug, supplement, or medical product, and it is not intended for human or animal use, or for diagnosing, treating, or preventing any condition.

In lab studies, MOTS-c is evaluated for how it communicates metabolic state and regulates cellular energy mechanisms:

• Retrograde Nuclear Translocation: Upon metabolic stress, MOTS-c translocates to the nucleus to interact with transcription factors such as NRF2.
• AMPK Pathway Signaling: Evaluated in cell assays for its role in stimulating AMPK phosphorylation, independent of the classical insulin signaling pathway.
• Folate & Purine Metabolism: Studied for its regulatory impact on the folate cycle and de novo purine biosynthesis in metabolic research models.

Please note that this research is preclinical (cell and lab work). This information is shared for educational purposes only.

• Product: MOTS-c research peptide
• Vial Size: 10 mg
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• CAS Number: 1627580-64-6
• Molecular Weight: ~2,174.6 g/mol
• Format: Freeze-dried (lyophilized) powder in a sealed glass vial
• Purity: ≥ 98.0% (verified by HPLC testing)
• Testing: See the Certificate of Analysis (COA) button above for this batch’s test results

Store sealed vials at -20°C (-4°F) or colder for long-term stability. Keep them dry and away from direct light. Avoid repeated temperature swings, which can break the peptide down over time.